Greenville County is located in South Carolina's District 4. Those who are running for the US House of Representatives for the upcoming election are:
- Paul Corden - Democrat
- Steven Edwards - Libertarian
- Trey Gowdy - Republican
- Bob Inglis - Republican - Incumbent
- Christina Jeffrey - Republican
- Jim Lee - Republican
- David Thomas - Republican
- C. Faye Walters - Green Party
South Carolina has two US Senate seats. The seat currently occupied by Jim DeMint will be up for reelection in 2010.
- Tom Clements - Green Party
- Jim DeMint - Republican, Incumbent
- Susan Gaddy - Republican
- Alvin Michael Greene - Democrat
- Vic Rawl - Democrat
